Endocrine Abstracts

Introduction: Paediatric Cushing’s disease is rare and up to 50% have incomplete cure.1 Besides hypopituitarism growth failure is particularly common and maybe due to GH deficiency, target tissue resistance2 or accelerated skeletal maturation 3. Our patient is an 18-year-old obese male who first presented at the age of 16 with delayed puberty and short stature.Results: His 24 hr urinary cortisol was 1472 nmol/l, ACTH...

Craniofacial proportions of girls with TS, compared to normal children, show reduced size of the craniofacial complex, retrognathic profile and tendency towards advanced dental age. Growth hormone (GH) treatment in TS positively affects stature, but its effects on craniofacial growth and dental development are largely unknown. The aim of this study was to analyze and to correlate the craniofacial morphology, chronological, dental and bone ages of TS patients receiving GH or no...

Purpose: To evaluate the relationship between basal dehydroepiandrosterone-sulfate (DHEA-S) levels and other tests used in the diagnosis and differential diagnosis of Cushing’s Syndrome (CS) among the patients with pathologically confirmed CS.Methods: In this multicenter study, the data of 623 patients with CS were evaluated retrospectively. The patients were classified as Group 1 (n = 353 Cushing’s disease;CD), Group 2 (n</e...

A 31-year-old man without previous medical history presented to his local hospital with one week history of generalised severe headache. Brain CT was reported as negative for acute intracranial pathology. Five weeks later, he re-presented with worsening headache and blurring of vision. Brain CT revealed a large area of hypodensity centred on the left thalamus/basal ganglia and subsequent MRI with contrast showed a medium size pituitary cyst with suprasellar extension and two c...

Introduction: Cushing’s syndrome (CS) is accompanied by a ten times increased risk of venous thromboembolism and arterial thrombosis. In this study we aimed to analyze frequency of thromboembolism in CS.Methods: We prospectively followed 62 patients who had been diagnosed with CS between 2010 and 2014 in our clinic. Of the patients, 60% had Cushing’s disease (CD) (29 females and eight males) and 40% had ACTH-independent CS (20 females and five ...

Background: In steroid dependent patients the knowledge of steroid dose change during illness and stress is of paramount importance.Objectives: i) To assess patient’s knowledge of steroid management during acute illness and stressful condition. ii) To evaluate whether there is a relation between patient knowledge and admission with documented adrenal crisis. iii) To improve medical access to information about patients on steroid at Emergency Departm...

Introduction: Paraneoplastic Cushing’ syndrome (CS) represents 5–10% of all CS and has a severe prognosis due to severe metabolic imbalance, denutrition, associated infections, and progression of tumoural underlying pathology.A 67 years old woman presented with mental confusion, progressive weight loss, severe oedema and kypokalaemia, without typical features of Cushing or hyperpigmentation. Investigations revealed paraneoplastic Cushing’s...

In autoimmune thyroid disease some diverse neurological alterations like dementia, psychosis or peripheral neuropathy, are described. Hashimoto’s encephalopathy (EH) is a serious form of these neurological alterations. We describe three cases with different presentation and morphologic normal tests where cerebral SPECT was diagnostic.Case n°1. A 32-year-old male diagnosed of autoimmune hypothyroidism which presents paresthetics and muscular sti...

IntroductionRecent studies in patients with Addison’s disease (AD) have shown that this condition, even if treated, is fraught with significant morbidity. In this context, we report a retrospective study which concerned 32 patients with AD in order to determine the deleterious effects of long-term glucocorticoid substitution, mainly on the occurrence of type 2 diabetes.ResultsIn the 32 patients followed ...

A 36 year old man presented with a six month history of palpitations. An ECG in a different hospital had showed a sinus tachycardia. An echocardiogram had also been performed and reported as normal. There were no apparent clinical features to suggest Cushing’s Syndrome (BMI 26 kg/m2). Resting pulse was 86/min. BP was 140/90. Examination was otherwise unremarkable.Baseline biochemical and haematological investigations including TFT, FBC we...